Population Genetics in the Human Microbiome

Human Genetics Shape the Gut Microbiome

Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear. Here, we compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs. We identified many microbial taxa whose abundances were influenced by ho...

Human Microbiome

Humans are almost identical in their genetic pattern, but the slight differences in our DNA lead to remarkable phenotypic variation among the human population. There are a variety of microbial communities and their genes (microbiomes) in the human body that play an essential role in human health and disease. The microbes inhabiting our bodies is quite a bit more variable, with only a third of i...

Microbiome genetics underpins chemotherapy

SUTTER The Relationship Between Human Population Genetics

~eneral terms. It might even be said that this aspect of research is frequently neglected. Blood-group experts are undoubtedly most directly responsible for this regrettable situation. Since one applies Fisher's formulas on the assumption that the blood groups are independent of age and sex, there is a tendency to confine research to any random sample of the population, which is only rarely rep...

Going the distance: human population genetics in a clinal world.

Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these 'clines' can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography in...